ATP Binding Cassette Transporter C2 (ABCC2)

CMOAT1; ABC30; CMOAT; DJS; MRP2; cMRP; Canalicular Multispecific Organic Anion transporter 1; Canalicular multidrug resistance protein; Multidrug resistance-associated 2

SPN	T162
HGNC	53
MGI	1352447
PubMed	20082599
RGD	2366
UniProt	Q92887
Wiki	ABCC2

ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).his protein is a member of the MRP subfamily, which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells.Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Reference

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"Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome."
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"Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene."
Pediatr. Int. 56:E62-E62(2014) [PubMed] [Europe PMC] [Abstract]