ATP Binding Cassette Transporter C5 (ABCC5)

ABC-C5; ABC33; MOAT-C; MOATC; MRP5; SMRP; pABC11; Multidrug Resistance-Associated Protein 5; Multi-specific organic anion transporter C

SPN	T159
HGNC	56
MGI	1351644
PubMed	15897250
RGD	70913
UniProt	O15440
Wiki	ABCC5

ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Reference

"Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins."
J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed] [Europe PMC] [Abstract]

"pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells."
J. Biol. Chem. 274:23541-23548(1999) [PubMed] [Europe PMC] [Abstract]

"Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]

"Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]

"Three novel ABCC5 splice variants in human retina and their role as regulators of ABCC5 gene expression."
BMC Mol. Biol. 8:42-42(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line."
Biochem. Biophys. Res. Commun. 238:790-794(1997) [PubMed] [Europe PMC] [Abstract]

"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]