ATP Binding Cassette Transporter G4 (ABCG4)

ABC-G4; WHITE2; ATP-Binding Cassette,Sub-Family G(WHITE)Member 4; Putative ABC Transporter

SPN	T127
HGNC	13884
MGI	1890594
PubMed	11856881
RGD	1305840
UniProt	Q9H172
Wiki	ABCG4

ATP-binding cassette sub-family G member 4 is a protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).

This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. Engel et al. (2001) demonstrated 5-fold induction of ABCG4 following treatment of normal monocyte-derived macrophages with the LXR and RXR agonists 9-cis retinoic acid and 22R hydroxycholesterol.

Reference

"The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages."
Biochem. Biophys. Res. Commun. 288:483-488(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4."
Cytogenet. Cell Genet. 94:196-201(2001) [PubMed] [Europe PMC] [Abstract]

"ABCG4: a novel human white family ABC-transporter expressed in the brain and eye."
Biochim. Biophys. Acta 1591:175-179(2002) [PubMed] [Europe PMC] [Abstract]