Acyl Coenzyme A Dehydrogenase, C4-To-C12 Straight Chain (ACADM)

MCAD; MCADH; ACAD1; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

SPN	T122
HGNC	89
MGI	87867
PubMed	15832312
RGD	2012
UniProt	P11310
Wiki	ACADM

acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as milk and certain oils, and they are also stored in the body's fat tissue. Medium-chain fatty acids are also produced when larger fatty acids are degraded. The acyl-coenzyme A dehydrogenase for medium-chain fatty acids (ACADM) enzyme is essential for converting these particular fatty acids to energy, especially during periods without food (fasting). The ACADM enzyme functions in mitochondria, the energy-producing centers within cells. It is found in the mitochondria of several types of tissues, particularly the liver.

Reference

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, Submitted (MAR-2007) to UniProtKB

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"Molecular basis of medium chain acyl-coenzyme A dehydrogenase deficiency. An A to G transition at position 985 that causes a lysine-304 to glutamate substitution in the mature protein is the single prevalent mutation."
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