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Coenzyme A Synthase (COASY)

NBP; PPAT; DPCK; UKR1; pOV-2; DPCOAK; Phosphopantetheine adenylyltransferase; Dephospho-CoA pyrophosphorylase; Dephospho-CoA kinase; Dephosphocoenzyme A kinase

COASY has been shown to interact with P70-S6 Kinase 1. COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.
Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Hu01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Hu01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Hu01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Hu01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Hu01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Mu01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Mu01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Mu01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Mu01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Mu01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Ra01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Ra01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Ra01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Ra01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Ra01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Ca01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Ca01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Ca01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Ca01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Ca01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Po01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Po01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Po01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Po01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Po01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Bo01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Bo01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Bo01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Bo01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Bo01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Rb01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Rb01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Rb01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Rb01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Rb01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT116Mo01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT116Mo01 Monoclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
PAT116Mo01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IF.
Assay Kits CLT116Mo01 CLIA Kit for Coenzyme A Synthase (COASY) CLIA assay for Antigen Detection
ELT116Mo01 ELISA Kit for Coenzyme A Synthase (COASY) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics."
J. Biol. Chem. 277:21431-21439(2002) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)."
Biochem. J. 365:13-18(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase."
Hum. Genet. 96:532-538(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel CoA synthase isoform, which is primarily expressed in the brain."
Biochem. Biophys. Res. Commun. 341:995-1000(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation."
Am. J. Hum. Genet. 94:11-22(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]