3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH)
Beta-Hydroxyisobutyryl-CoA Hydrolase
Beta-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) is responsible for the specific hydrolysis of HIBYL-CoA, a valine catabolite, as well as the hydrolysis of beta-hydroxypropionyl-CoA, an intermediate in a minor pathway of propionate metabolism.
The protein contains a 28-amino acid mitochondrial leader sequence and shows significant homology with the enoyl-CoA hydratase/isomerase enzyme family. Northern blot analysis revealed expression of an approximately 2-kb transcript, with highest expression in skeletal muscle, followed by liver, heart, kidney, and brain. Western blot analysis also demonstrated tissue-specific expression but with quantitatively different tissue distribution that was most apparent in soleus muscle.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Hu01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Hu01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Hu01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Hu01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Hu01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Mu01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Mu01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Mu01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Mu01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Mu01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Ra01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Ra01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Ra01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Ra01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Ra01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Ca01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Ca01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Ca01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Ca01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Ca01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Po01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Po01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Po01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Po01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Po01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Bo01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Bo01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Bo01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Bo01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Bo01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Rb01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Rb01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Rb01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Rb01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Rb01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT101Mo01 | Recombinant 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT101Mo01 | Monoclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IP. |
| PAT101Mo01 | Polyclonal Antibody to 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT101Mo01 | CLIA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | CLIA assay for Antigen Detection |
| ELT101Mo01 | ELISA Kit for 3-Hydroxyisobutyryl Coenzyme A Hydrolase (HIBCH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human beta-hydroxyisobutyryl-COA hydrolase in complex with quercetin."
Submitted (JAN-2008) to the PDB data bank
"Mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration."
Am. J. Hum. Genet. 80:195-199(2007) [PubMed] [Europe PMC] [Abstract]