Regulator Of G Protein Signaling 10 (RGS10)

SPN	T084
HGNC	9992
MGI	1915115
PubMed	8774883
RGD	3562
UniProt	O43665
Wiki	RGS10

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. RGS10 associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Reference

"RGS10 is a selective activator of G alpha i GTPase activity."
Nature 383:175-177(1996) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs."
J. Biol. Chem. 275:24013-24021(2000) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)."
J. Biol. Chem. 276:32828-32834(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10."
J. Biol. Chem. 274:38260-38267(1999) [PubMed] [Europe PMC] [Abstract]

"Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits."
Science 278:1132-1135(1997) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the RGS domain of human regulator of G-protein signaling 10."
Submitted (OCT-2006) to the PDB data bank