Regulator Of G Protein Signaling 7 (RGS7)

SPN	T077
HGNC	10003
MGI	1346089
PubMed	11032900
RGD	3570
UniProt	P49802
Wiki	RGS7

EGL-10 shares a region of homology with yeast Sst2p, which regulates G protein signaling, so they named the common domain 'RGS' for 'regulator of G protein signaling similarity domain'. The authors noted that several other proteins, including human RGS1 and RGS2, contain this domain. They identified additional human genes encoding the RGS domain by searching a database of expressed sequence tags (ESTs). They cloned a partial 1.9-kb cDNA, designated RGS7, that contains a 420-codon open reading frame encoding a protein with 53% identity to EGL-10. The homology between RGS7 and EGL-10 extends beyond the RGS domain. Northern blotting of rat mRNA showed that RGS7 is expressed primarily in brain, with lower levels in lung, as a 2.7-kb mRNA.

Reference

"Interaction between RGS7 and polycystin."
Proc. Natl. Acad. Sci. U.S.A. 96:6371-6376(1999) [PubMed] [Europe PMC] [Abstract]

"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins."
Cell 84:115-125(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."
Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]

"14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity."
J. Biol. Chem. 275:28167-28172(2000) [PubMed] [Europe PMC] [Abstract]

"Snapin interacts with the N-terminus of regulator of G protein signaling 7."
Biochem. Biophys. Res. Commun. 303:594-599(2003) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the RGS domain of regulator of G-protein signaling 7."
Submitted (DEC-2006) to the PDB data bank