Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3)
CD158B2; Cl-6; Nkat2; Nkat2a; Nkat2b; p58; CD158 antigen-like family member B2; MHC class I NK cell receptor; Natural killer-associated transcript 2
By RT-PCR screening of NK cells with primers based on the KIR2DL1 sequence, Colonna and Samaridis (1995) identified a KIR2DL3 cDNA, which they called NKAT2, encoding a deduced 341-amino acid type I transmembrane protein. Sequence analysis revealed a structure similar to that described for KIR2DL1, with a 21-amino acid signal peptide, an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with 2 ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Using tryptic peptide sequences from p58 and degenerate PCR primers to screen an NK cell cDNA library, Wagtmann et al. (1995) independently isolated a KIR2DL3 cDNA, which they called clone 6 (CL6). Dohring et al. (1996) identified splice variants of NKAT2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Hu01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Hu01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Hu01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Hu01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Hu01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Mu01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Mu01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Mu01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Mu01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Mu01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Ra01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Ra01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Ra01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Ra01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Ra01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Ca01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Ca01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Ca01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Ca01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Ca01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Po01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Po01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Po01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Po01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Po01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Bo01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Bo01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Bo01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Bo01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Bo01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Rb01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Rb01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Rb01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Rb01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Rb01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT075Mo01 | Recombinant Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT075Mo01 | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IP. |
| PAT075Mo01 | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT075Mo01 | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | CLIA assay for Antigen Detection |
| ELT075Mo01 | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
"Alternatively spliced forms of human killer inhibitory receptors."
Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
"Human diversity in killer cell inhibitory receptor genes."
Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]
"Polymorphism and domain variability of human killer cell inhibitory receptors."
Immunol. Rev. 155:183-196(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of a human killer cell inhibitory receptor gene."
Tissue Antigens 49:574-579(1997) [PubMed] [Europe PMC] [Abstract]
"An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I."
Structure 7:391-398(1999) [PubMed] [Europe PMC] [Abstract]