Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2)

CD158J; Cl-49; Nkat5; 183ActI; CD158 antigen-like family member J; MHC class I NK cell receptor; Natural killer-associated transcript 5; NK receptor 183 ActI

SPN	T072
HGNC	6334
PubMed	19877200
UniProt	P43631

KIR2DS2 encodes a deduced 304-amino acid transmembrane protein. Sequence analysis revealed that the extracellular domain is similar to that of KIR2D p58 receptors; however, in the transmembrane region, there is a charged lysine residue, and the cytoplasmic tail has only 39 amino acids with no ITIM (immunoreceptor tyrosine-based inhibitory motif). KIRs with short cytoplasmic tails are associated with NK cell triggering rather than inhibition. Immunoprecipitation and Western blot analyses of KIR2DS2 expressed in COS cells revealed a 50-kD protein. Flow cytometric analysis confirmed surface expression of KIR2DS2. Biassoni et al. (1996) pointed out that receptors with identical HLA-C allele specificity can mediate opposite functions owing to their different transmembrane/cytoplasmic regions.

Reference

"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]

"The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."
J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]

"Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes."
J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)."
J. Exp. Med. 197:933-938(2003) [PubMed] [Europe PMC] [Abstract]