Lipolysis Stimulated Lipoprotein Receptor (LSR)

LISCH7; ILDR3; LISCH; Lipolysis-Stimulated Remnant; Immunoglobulin-Like Domain Containing Receptor 3

SPN	T041
HGNC	29572
MGI	1927471
PubMed	22671589
RGD	69236
UniProt	Q86X29
Wiki	LSR

LSR is a multimeric protein complex in the liver that undergoes conformational changes upon binding of free fatty acids, thereby revealing a binding site (s) that recognizes both apoB and apoE. Complete inactivation of the LSR gene is embryonic lethal in mice.LSR cooperates with the LDL receptor in the final hepatic processing of apoB-containing lipoproteins and represents a novel therapeutic target for the treatment of hyperlipidemia associated with obesity and atherosclerosis. The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids. Antibodies inhibiting LSR functions showed that the receptor is a heterotrimer or tetramer consisting of 68-kDa (alpha) and 56-kDa (beta) subunits associated through disulfide bridges.

Reference

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