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Asparagine Synthetase (ASNS)

Aspartate-Ammonia Ligase; Asparagine synthetase [glutamine-hydrolyzing]; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase

Asparagine synthetase is an enzyme that generates asparagine from aspartate. This amidation reaction is similar to that promoted by glutamine synthetase.human ASNS based on its ability to complement ts11, a temperature-sensitive (ts) mutant of the BHK hamster cell line that at the nonpermissive temperature is blocked in progression through the G1 phase of the cell growth cycle. The gene was transcribed into an mRNA of 2 kb that was expressed in all human, hamster, and mouse cell lines tested. It encodes a protein of about 550 amino acids.The 5-prime upstream region of this gene, like other housekeeping genes, lacks conventional TATA and CAAT boxes. Both the human and the hamster genes have a high 5-prime G+C content which may play a role in expression through DNA methylation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T025Hu01 Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies MT025Hu21 Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
PT025Hu01 Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits KET025Hu ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
PT025Mu01 Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits KET025Mu ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Asparagine Synthetase (ASNS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Asparagine Synthetase (ASNS) Bioactivity
Antibodies NONE Monoclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Asparagine Synthetase (ASNS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Asparagine Synthetase (ASNS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Asparagine Synthetase (ASNS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Asparagine Synthetase (ASNS) CLIA assay for Antigen Detection

Reference

"Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells."
Mol. Cell. Biol. 7:2435-2443(1987) [PubMed] [Europe PMC] [Abstract]

"Molecular structure of the human asparagine synthetase gene."
Genomics 4:259-265(1989) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a gene that is necessary for G1 progression in mammalian cells."
Proc. Natl. Acad. Sci. U.S.A. 84:1565-1569(1987) [PubMed] [Europe PMC] [Abstract]

"Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase."
Mol. Cell. Biol. 9:2350-2359(1989) [PubMed] [Europe PMC] [Abstract]

"Expression of human asparagine synthetase in Escherichia coli."
J. Biol. Chem. 264:5503-5509(1989) [PubMed] [Europe PMC] [Abstract]

"The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity."
J. Biol. Chem. 264:19475-19477(1989) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy."
Neuron 80:429-441(2013) [PubMed] [Europe PMC] [Abstract]