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Kynureninase (KYNU)
Kynureninase (KYNU)
L-Kynurenine Hydrolase
Kynureninase is a PLP dependent enzyme that catalyses the cleavage of Kyn into Ant. It can also act on 3hKyn (to produce 3hAnt) and some other (3-arylcarbonyl)-alanines.KYNU is part of the pathways for the catabolism of Trp and the biosynthesis of NAD cofactors from Trp. In KYNU reaction, PLP facilitates Cβ -Cγ bond cleavage. The reaction follows the same steps as the transamination reaction but does not hydrolyze the tautomerized Schiff base. The proposed reaction mechanism involves an attack of an enzyme nucleophile on the carbonyl carbon (Cγ ) of the tautomerized 3hKyn-PLP Schiff base. This is followed by Cβ -Cγ bond cleavage to generate an acyl-enzyme intermediate together with a tautomerized Ala-PLP adduct. Hydrolysis of the acyl-enzyme then yields 3hAnt.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
T023Hu01
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
MT023Hu21
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
PT023Hu01
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
KET023Hu
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kynureninase (KYNU) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kynureninase (KYNU) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kynureninase (KYNU) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kynureninase (KYNU) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kynureninase (KYNU) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kynureninase (KYNU) CLIA assay for Antigen Detection
Reference
"Isolation and expression of a cDNA clone encoding human kynureninase." Eur. J. Biochem. 239:460-468(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Cloning and recombinant expression of rat and human kynureninase." FEBS Lett. 408:5-10(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Purification and biochemical characterization of some of the properties of recombinant human kynureninase." Eur. J. Biochem. 269:2069-2074(2002) [PubMed ] [Europe PMC ] [Abstract ]
"Initial characterization of the human central proteome." BMC Syst. Biol. 5:17-17(2011) [PubMed ] [Europe PMC ] [Abstract ]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed ] [Europe PMC ] [Abstract ]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome." J. Proteomics 96:253-262(2014) [PubMed ] [Europe PMC ] [Abstract ]
"Crystal structure of Homo sapiens kynureninase." Biochemistry 46:2735-2744(2007) [PubMed ] [Europe PMC ] [Abstract ]
"Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase." J. Inherit. Metab. Dis. 30:248-255(2007) [PubMed ] [Europe PMC ] [Abstract ]
