Preprooxytocin (OT)

OXT; Oxytocin,Prepropeptide; Oxytocin,Prepro-Neurophysin I; Oxytocin-Neurophysin 1

SPN	T018
HGNC	8528
MGI	97453
PubMed	17400809
RGD	3238
UniProt	P01178

There are two proteins encoded by OT gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Hu01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Hu01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Hu01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Hu01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Hu01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Mu01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Mu01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Mu01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Mu01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Mu01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Ra01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Ra01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Ra01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Ra01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Ra01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Ca01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Ca01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Ca01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Ca01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Ca01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Po01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Po01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Po01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Po01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Po01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Bo01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Bo01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Bo01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Bo01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Bo01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Rb01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Rb01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Rb01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Rb01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Rb01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT018Mo01	Recombinant Preprooxytocin (OT)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT018Mo01	Monoclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IP.
Antibodies	PAT018Mo01	Polyclonal Antibody to Preprooxytocin (OT)	WB; IHC; ICC; IF.
Assay Kits	CLT018Mo01	CLIA Kit for Preprooxytocin (OT)	CLIA assay for Antigen Detection
Assay Kits	ELT018Mo01	ELISA Kit for Preprooxytocin (OT)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation."
Biol. Chem. Hoppe-Seyler 367:695-704(1986) [PubMed] [Europe PMC] [Abstract]

"The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line."
J. Biol. Chem. 260:10236-10241(1985) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues."
Endocrinology 127:2990-2996(1990) [PubMed] [Europe PMC] [Abstract]

"Expression of the vasopressin and oxytocin genes in human hypothalami."
FEBS Lett. 193:12-16(1985) [PubMed] [Europe PMC] [Abstract]

"Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins."
Proc. Natl. Acad. Sci. U.S.A. 80:2839-2843(1983) [PubMed] [Europe PMC] [Abstract]

"A comparative study of mammalian neurophysin protein sequences."
FEBS Lett. 128:325-328(1981) [PubMed] [Europe PMC] [Abstract]

"On the nature of oxytocin and vasopressin from human pituitary."
Proc. Soc. Exp. Biol. Med. 98:692-696(1958) [PubMed] [Europe PMC] [Abstract]