High Mobility Group Box Protein 3 (HMGB3)
HMG2A; HMG4; High mobility group protein 4
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 and HMG2 , HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription .Vaccari et al. (1998) isolated mouse and human cDNAs corresponding to HGM2A, which they called HMG4. They reported that the deduced mouse and human proteins contain 200 amino acids and are 97% identical. Northern blot and RT-PCR analyses suggested that mouse Hmg4 transcripts are much more abundant in embryonic than in adult tissues. Hmgb3 was preferentially expressed in mouse hematopoietic stem cells (HSCs) and that it was expressed in adult mouse bone marrow cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Hu01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Hu01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Hu01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Hu01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Hu01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Mu01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Mu01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Mu01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Mu01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Mu01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Ra01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Ra01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Ra01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Ra01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Ra01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Ca01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Ca01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Ca01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Ca01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Ca01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Po01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Po01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Po01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Po01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Po01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Bo01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Bo01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Bo01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Bo01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Bo01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Rb01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Rb01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Rb01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Rb01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Rb01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT012Mo01 | Recombinant High Mobility Group Box Protein 3 (HMGB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT012Mo01 | Monoclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IP. |
| PAT012Mo01 | Polyclonal Antibody to High Mobility Group Box Protein 3 (HMGB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT012Mo01 | CLIA Kit for High Mobility Group Box Protein 3 (HMGB3) | CLIA assay for Antigen Detection |
| ELT012Mo01 | ELISA Kit for High Mobility Group Box Protein 3 (HMGB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region."
Gene 198:269-274(1997) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the first and second HMG-box domain from high mobility group protein B3."
Submitted (APR-2008) to the PDB data bank
"Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene."
Am. J. Hum. Genet. 87:146-153(2010) [PubMed] [Europe PMC] [Abstract]
"Identification of an HMGB3 frameshift mutation in a family with an X-linked colobomatous microphthalmia syndrome using whole-genome and X-exome sequencing."
JAMA Ophthalmol. 132:1215-1220(2014) [PubMed] [Europe PMC] [Abstract]