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Tryptase Beta 2 (TPSb2)

TPS2; Tryptase Beta II; Tryptase Beta III

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors.
TPSb2 is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Hu01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Hu01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Hu01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Hu01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Hu01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Mu01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Mu01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Mu01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Mu01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Mu01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Ra01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Ra01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Ra01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Ra01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Ra01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Ca01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Ca01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Ca01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Ca01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Ca01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Po01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Po01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Po01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Po01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Po01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Bo01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Bo01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Bo01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Bo01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Bo01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Rb01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Rb01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Rb01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Rb01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Rb01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT004Mo01 Recombinant Tryptase Beta 2 (TPSb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT004Mo01 Monoclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IP.
PAT004Mo01 Polyclonal Antibody to Tryptase Beta 2 (TPSb2) WB; IHC; ICC; IF.
Assay Kits CLT004Mo01 CLIA Kit for Tryptase Beta 2 (TPSb2) CLIA assay for Antigen Detection
ELT004Mo01 ELISA Kit for Tryptase Beta 2 (TPSb2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization of a second complementary DNA for human tryptase."
J. Clin. Invest. 86:864-870(1990) [PubMed] [Europe PMC] [Abstract]

"Characterization of a tryptase mRNA expressed in the human basophil cell line KU812."
Scand. J. Immunol. 37:203-208(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."
J. Biol. Chem. 274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]

"Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."
J. Allergy Clin. Immunol. 124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."
Proc. Natl. Acad. Sci. U.S.A. 87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]

"Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]

"Active monomers of human beta-tryptase have expanded substrate specificities."
Int. Immunopharmacol. 7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]

"Human beta-tryptase is a ring-like tetramer with active sites facing a central pore."
Nature 392:306-311(1998) [PubMed] [Europe PMC] [Abstract]

"The structure of the human betaII-tryptase tetramer: fo(u)r better or worse."
Proc. Natl. Acad. Sci. U.S.A. 96:10984-10991(1999) [PubMed] [Europe PMC] [Abstract]