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Topoisomerase III (TOP3)

TOP3A; DNA topoisomerase III alpha

DNA topoisomerase 3-alpha is ana DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.High expression is found in testis, heart, skeletal muscle and pancreas. Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Hu01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Hu01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Hu01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Hu01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Hu01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Mu01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Mu01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Mu01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Mu01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Mu01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Ra01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Ra01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Ra01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Ra01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Ra01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Ca01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Ca01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Ca01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Ca01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Ca01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Po01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Po01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Po01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Po01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Po01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Bo01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Bo01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Bo01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Bo01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Bo01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Rb01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Rb01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Rb01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Rb01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Rb01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS984Mo01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS984Mo01 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
PAS984Mo01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IF.
Assay Kits CLS984Mo01 CLIA Kit for Topoisomerase III (TOP3) CLIA assay for Antigen Detection
ELS984Mo01 ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human TOP3: a single-copy gene encoding DNA topoisomerase III."
Proc. Natl. Acad. Sci. U.S.A. 93:3653-3657(1996) [PubMed] [Europe PMC] [Abstract]

"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity."
EMBO J. 24:1465-1476(2005) [PubMed] [Europe PMC] [Abstract]

"RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability."
Genes Dev. 22:2843-2855(2008) [PubMed] [Europe PMC] [Abstract]

"BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome."
Genes Dev. 22:2856-2868(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1."
J. Biol. Chem. 285:21426-21436(2010) [PubMed] [Europe PMC] [Abstract]

"Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair."
Proc. Natl. Acad. Sci. U.S.A. 110:10646-10651(2013) [PubMed] [Europe PMC] [Abstract]