Topoisomerase II Binding Protein 1 (TOPBP1)
TOP2BP1; DNA topoisomerase II-beta-binding protein 1
TOPBP1 is a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.The deduced 1,522-amino acid protein has a calculated molecular mass of about 171 kD. TOPBP1 contains 8 repeating regions throughout its sequence that share similarity with repeat regions 1 and 2 of Rad4. It also has an auto-ADP-ribosylation site and 2 C-terminal nuclear localization signals. The 3-prime untranslated region contains 12 AUUUA mRNA-instability motifs. Northern blot analysis detected ubiquitous expression, with smearing characteristic of unstable mRNA. Transcripts above 10 kb were detected only in heart.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | S983Hu01 | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| PS983Hu01 | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | S983Mu01 | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| PS983Mu01 | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | S983Ra01 | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| PS983Ra01 | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Topoisomerase II Binding Protein 1 (TOPBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Topoisomerase II Binding Protein 1 (TOPBP1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Topoisomerase II Binding Protein 1 (TOPBP1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Topoisomerase II Binding Protein 1 (TOPBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Topoisomerase II Binding Protein 1 (TOPBP1) | CLIA assay for Antigen Detection |
Reference
"A DNA topoisomerase II binding protein with eight repeating regions similar to DNA repair enzymes and to a cell cycle regulator."
Eur. J. Biochem. 250:794-799(1997) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA."
Oncogene 18:5194-5203(1999) [PubMed] [Europe PMC] [Abstract]
"BRCT domain-containing protein TopBP1 functions in DNA replication and damage response."
J. Biol. Chem. 276:30399-30406(2001) [PubMed] [Europe PMC] [Abstract]
"Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response."
J. Biol. Chem. 277:3599-3605(2002) [PubMed] [Europe PMC] [Abstract]
"Regulation of E2F1 by BRCT domain-containing protein TopBP1."
Mol. Cell. Biol. 23:3287-3304(2003) [PubMed] [Europe PMC] [Abstract]
"PML colocalizes with and stabilizes the DNA damage response protein TopBP1."
Mol. Cell. Biol. 23:4247-4256(2003) [PubMed] [Europe PMC] [Abstract]
"TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis."
Chromosoma 112:323-330(2004) [PubMed] [Europe PMC] [Abstract]
"TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival."
Genes Dev. 18:673-686(2004) [PubMed] [Europe PMC] [Abstract]
"TopBP1 activates the ATR-ATRIP complex."
Cell 124:943-955(2006) [PubMed] [Europe PMC] [Abstract]
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"A vertebrate gene, ticrr, is an essential checkpoint and replication regulator."
Genes Dev. 24:183-194(2010) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling."
Science 332:1313-1317(2011) [PubMed] [Europe PMC] [Abstract]
"The third BRCA1 C-terminus (BRCT) domain of topoisomerase II binding protein."
Submitted (NOV-2004) to the PDB data bank
"Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1."
Protein Sci. 19:162-167(2010) [PubMed] [Europe PMC] [Abstract]