Basic Salivary Proline Rich Protein 1 (PRB1)

PM; PMF; PMS; PRB1L; PRB1M; Ps 1; Ps 2; PRPPRB1; Ps; cP7; Proline-Rich Protein BstNI Subfamily 1

SPN	S974
HGNC	9337
MGI	2681872
PubMed	9045801
RGD	628797
UniProt	P04280
Wiki	PRB1

Proline-rich proteins fall into acidic and basic groups. The 2 genes that encode acidic proteins are PRH1 and PRH2. and these genes contain repeated sequences that have a cleavage site for the restriction enzyme HaeIII.The PRH1 locus codes for the Pa, Db, and PIF proteins. The PRH2 locus codes for the Pr protein. The 4 genes that encode basic proline-rich proteins are PRB1, PRB2, PRB3, and PRB4, and these genes contain repeated sequences that have a cleavage site for the restriction enzyme BstNI.

The PRB1 locus encodes the PmF, PmS, Pe, and Con2 proteins. The PRB2 locus encodes the Ps and Con1 proteins. The PRB3 locus encodes the G1 protein. The PRB4 locus encodes the Po protein.

Reference

"Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system."
J. Biol. Chem. 260:11123-11130(1985) [PubMed] [Europe PMC] [Abstract]

"The structure and evolution of the human salivary proline-rich protein gene family."
Mamm. Genome 4:3-14(1993) [PubMed] [Europe PMC] [Abstract]

"Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual."
Biochemistry 30:3351-3356(1991) [PubMed] [Europe PMC] [Abstract]

"Clones from the human gene complex coding for salivary proline-rich proteins."
Proc. Natl. Acad. Sci. U.S.A. 81:5561-5565(1984) [PubMed] [Europe PMC] [Abstract]

"Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over."
Genetics 120:267-278(1988) [PubMed] [Europe PMC] [Abstract]

"PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)."
Am. J. Hum. Genet. 53:264-278(1993) [PubMed] [Europe PMC] [Abstract]

"Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6."
Biochemistry 25:2387-2392(1986) [PubMed] [Europe PMC] [Abstract]

"Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H."
J. Biochem. 94:1991-1999(1983) [PubMed] [Europe PMC] [Abstract]

"Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases."
J. Biol. Chem. 283:19957-19966(2008) [PubMed] [Europe PMC] [Abstract]

"Finding new posttranslational modifications in salivary proline-rich proteins."
Proteomics 10:3732-3742(2010) [PubMed] [Europe PMC] [Abstract]