Thrombospondin 2 (THBS2)

TSP2

SPN	S952
HGNC	11786
MGI	98738
PubMed	18955754
RGD	1310979
UniProt	P35442
Wiki	THBS2

Thrombospondin was originally discovered as a secretory product of platelet alpha-granules. It is a multifunctional protein that contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin, etc. It functions in many cell adhesion and migration events, including platelet aggregation. Thrombospondin-2 is a protein belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.

Reference

"Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region."
Genomics 17:225-229(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans."
Genomics 12:421-429(1992) [PubMed] [Europe PMC] [Abstract]

"Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."
Biochem. Biophys. Res. Commun. 182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]

"Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2."
J. Biol. Chem. 276:45882-45887(2001) [PubMed] [Europe PMC] [Abstract]

"A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation."
Am. J. Hum. Genet. 82:1122-1129(2008) [PubMed] [Europe PMC] [Abstract]

"CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo."
Breast Cancer Res. Treat. 128:337-346(2011) [PubMed] [Europe PMC] [Abstract]

"Structure of the calcium-rich signature domain of human thrombospondin-2."
Nat. Struct. Mol. Biol. 12:910-914(2005) [PubMed] [Europe PMC] [Abstract]

"Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability."
J. Biol. Chem. 283:20069-20076(2008) [PubMed] [Europe PMC] [Abstract]