Phospholipase C Like Protein 1 (PLCL1)

PLCE; PLC-L; PLCL; PRIP; Phospholipase C,Epsilon; Phospholipase C-deleted in lung carcinoma; Phospholipase C Related,But Catalytically Inactive Protein

SPN	S928
HGNC	9063
MGI	3036262
PubMed	18776929
UniProt	Q15111

Kohno et al. (1995) noted that the presence of a tumor suppressor gene in the 2q33 region had been suggested by a high incidence of allelic loss on 2q in lung carcinoma and the finding of a homozygous deletion at 2q33 in a small cell lung carcinoma cell line. They constructed a cosmid contig covering the homozygous deleted region, estimated at 220 kb, and identified a novel gene within this region. Since the gene encodes a protein with striking similarity to several members of a family of phospholipase C, they designated the gene PLCL for 'phospholipase C-deleted in lung carcinoma.' The PLCL gene was expressed in a variety of fetal and adult organs, including the lung. However, its expression was greatly reduced in 7 of 13 (53.8%) small cell lung carcinoma and 13 of 15 (86.7%) nonsmall cell lung carcinoma cell lines.

Reference

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Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

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"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha."
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"Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function."
EMBO J. 21:1004-1011(2002) [PubMed] [Europe PMC] [Abstract]

"PRIP, a novel Ins(1,4,5)P3 binding protein, functional significance in Ca2+ signaling and extension to neuroscience and beyond."
Mol. Cells 20:305-314(2005) [PubMed] [Europe PMC] [Abstract]

"Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein -- implications in the phospho-modulation of the GABAA receptor."
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"Characterization of the human PRIP-1 gene structure and transcriptional regulation."
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J. Biol. Chem. 281:22180-22189(2006) [PubMed] [Europe PMC] [Abstract]

"Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex."
J. Neurochem. 101:898-905(2007) [PubMed] [Europe PMC] [Abstract]