Lysophospholipase II (LYPLA2)

APT-2; LPL-II; Acyl-protein thioesterase 2

SPN	S926
HGNC	6738
MGI	1347000
PubMed	24624468
RGD	620210
UniProt	O95372

Lysophospholipids (LysoPLs) are detergent-like intermediates in phospholipid metabolism. Increased LysoPL levels have been detected in a variety of diseases including atherosclerosis and hyperlipidemia. In some cases, increased levels of LysoPLs are hypothesized to result from a dysfunction of LysoPL-regulating enzymes including lysophospholipases, which act on biologic membranes to regulate the level of LysoPLs by hydrolysis.

Lysophospholipase II act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity

Reference

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43."
PLoS ONE 5:E15045-E15045(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]