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Aspartate Aminotransferase 2 (AST2)

GOT2; MitAAT; KATIV; KAT4; FABP-1; Plasma membrane-associated fatty acid-binding protein; Glutamic-Oxaloacetic Transaminase 2,Mitochondrial; Kynurenine Aminotransferase IV

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.In lower animals and plants, many mitochondrial enzymes show maternal inheritance, indicating that a separate mitochondrial genetic system is involved in their control. However, family studies showed that mitochondrial GOT is under the control of nuclear not mitochondrial DNA. GOT2 has substrate and cofactor requirements very similar to those of cytosolic tyrosine aminotransferase. Indeed, GOT2 may be responsible for the TAT activity found in mitochondria .

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Hu01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Hu01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Hu01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Hu01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Hu01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Mu01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Mu01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Mu01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Mu01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Mu01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Ra01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Ra01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Ra01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Ra01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Ra01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Ca01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Ca01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Ca01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Ca01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Ca01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Po01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Po01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Po01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Po01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Po01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Bo01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Bo01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Bo01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Bo01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Bo01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Rb01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Rb01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Rb01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Rb01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Rb01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS921Mo01 Recombinant Aspartate Aminotransferase 2 (AST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS921Mo01 Monoclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IP.
PAS921Mo01 Polyclonal Antibody to Aspartate Aminotransferase 2 (AST2) WB; IHC; ICC; IF.
Assay Kits CLS921Mo01 CLIA Kit for Aspartate Aminotransferase 2 (AST2) CLIA assay for Antigen Detection
ELS921Mo01 ELISA Kit for Aspartate Aminotransferase 2 (AST2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA."
Biochem. Biophys. Res. Commun. 157:1309-1315(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The primary structure of mitochondrial aspartate aminotransferase from human heart."
Biochim. Biophys. Acta 832:46-51(1985) [PubMed] [Europe PMC] [Abstract]

"Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells."
Hepatology 27:1064-1074(1998) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]