Alanine Glyoxylate Aminotransferase 2 (AGXT2)
AGT2; Beta-Alanine-Pyruvate Aminotransferase; (R)-3-amino-2-methylpropionate--pyruvate transaminase
AGXT2 encodes the mitochondrial alanine-glyoxylate aminotransferase, which catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.The deduced 512-amino acid rat Agxt2 enzyme has a predicted 39-amino acid precursor leader sequence and has a calculated molecular mass of 57.15 kD. Rat Agxt2 shares 29.2% identity with rat ornithine aminotransferase (OAT1) but has little similarity to rat mitochondrial Agt1 or to human peroxisomal Agt1 (AGXT).Enzyme activity assay detected alanine-glyoxylate aminotransferase and glycolate reductase activity in purified mitochondria of liver carcinoma cells, and beta-ALAAT II activity was enriched in mitochondria, suggesting that human hepatocyte mitochondria possess AGXT2 activity.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Hu01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Hu01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Hu01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Hu01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Hu01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Mu01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Mu01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Mu01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Mu01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Mu01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Ra01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Ra01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Ra01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Ra01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Ra01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Ca01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Ca01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Ca01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Ca01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Ca01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Po01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Po01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Po01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Po01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Po01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Bo01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Bo01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Bo01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Bo01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Bo01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Rb01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Rb01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Rb01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Rb01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Rb01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS919Mo01 | Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS919Mo01 | Monoclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IP. |
| PAS919Mo01 | Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS919Mo01 | CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | CLIA assay for Antigen Detection |
| ELS919Mo01 | ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production."
J. Biol. Chem. 285:5385-5391(2010) [PubMed] [Europe PMC] [Abstract]
"Alanine-Glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure."
Arterioscler. Thromb. Vasc. Biol. 32:2892-2900(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population."
J. Atheroscler. Thromb. 21:1022-1030(2014) [PubMed] [Europe PMC] [Abstract]
"Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers."
PLoS ONE 9:E88544-E88544(2014) [PubMed] [Europe PMC] [Abstract]