Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1)

GFAT; GFA; •D-fructose-6-phosphate amidotransferase 1; Hexosephosphate aminotransferase 1; Glutamine-fructose-6-phosphate aminotransferase isomerizing 1

SPN	S909
HGNC	4241
MGI	95698
PubMed	23794683
RGD	1549703
UniProt	Q06210
Wiki	GFPT1

Glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes the formation of glucosamine 6-phosphate and is the first and rate-limiting enzyme of the hexosamine biosynthetic pathway. GFAT controls the flux of glucose into the hexosamine pathway, and thus formation of hexosamine products, and is most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Expression of these cDNA in E. coli produced a protein of approximately 77 kD and increased GFAT activity 4.5-fold over endogenous bacterial levels. Recombinant.

GFAT1L protein possessed functional GFAT activities and biochemical characteristics similar to those of GFAT1. Previously, GFAT1 was considered a simplex enzyme.

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel variant of glutamine:fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle."
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"Large-scale proteomics analysis of the human kinome."
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Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

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