Relaxin 3 (RLN3)

ZINS4; RXN3; H3; INSL7; Insulin-like peptide 7; Prorelaxin H3

SPN	S905
HGNC	17135
MGI	2158015
PubMed	19416197
RGD	628745
UniProt	Q8WXF3
Wiki	Relaxin-3

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin.
Relaxin 3 is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	PS905Mu01	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	MS905Ra21	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	PS905Ra01	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Relaxin 3 (RLN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Relaxin 3 (RLN3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Relaxin 3 (RLN3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Relaxin 3 (RLN3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Relaxin 3 (RLN3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Relaxin 3 (RLN3)	CLIA assay for Antigen Detection

Reference

"Production of recombinant human relaxin 3 in AtT20 cells."
Regul. Pept. 113:79-84(2003) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2."
J. Biol. Chem. 278:7855-7862(2003) [PubMed] [Europe PMC] [Abstract]

"Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135."
J. Biol. Chem. 278:50754-50764(2003) [PubMed] [Europe PMC] [Abstract]

"Identification of relaxin-3/INSL7 as a ligand for GPCR142."
J. Biol. Chem. 278:50765-50770(2003) [PubMed] [Europe PMC] [Abstract]

"Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3."
J. Biol. Chem. 281:5845-5851(2006) [PubMed] [Europe PMC] [Abstract]