Insulinoma Associated Protein 1 (INSM1)

IA1; Zinc finger protein IA-1

SPN	S898
HGNC	6090
MGI	1859980
PubMed	19542360
RGD	1309542
UniProt	Q01101
Wiki	INSM1

Insulinoma-associated protein 1 is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors

The insulinoma-associated 1 (INSM1) gene is expressed exclusively during early embryonal development, but has been found re-expressed at high levels in neuroendocrine tumors. The regulatory region of the INSM1 gene is therefore a potential candidate for regulating expression of a therapeutic gene in transcriptionally targeted cancer gene therapy against neuroendocrine tumors.

Reference

"A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs."
J. Biol. Chem. 267:15252-15257(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1."
J. Biol. Chem. 269:14170-14174(1994) [PubMed] [Europe PMC] [Abstract]

"Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence."
Nucleic Acids Res. 30:1038-1045(2002) [PubMed] [Europe PMC] [Abstract]

"NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system."
J. Biol. Chem. 278:38991-38997(2003) [PubMed] [Europe PMC] [Abstract]

"INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."
Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]

"IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas."
EMBO J. 25:1344-1352(2006) [PubMed] [Europe PMC] [Abstract]

"Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."
J. Endocrinol. 198:29-39(2008) [PubMed] [Europe PMC] [Abstract]

"Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."
J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]

"Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation."
FASEB J. 23:2024-2033(2009) [PubMed] [Europe PMC] [Abstract]

"Solution NMR structure of C2H2-type zinc-fingers 4 and 5 from human insulinoma-associated protein 1 (fragment 424-497), Northeast structural genomics consortium target HR7614B (Casp target)."
Submitted (OCT-2012) to the PDB data bank