General Transcription Factor IIIA (GTF3A)

AP2; TFIIIA

SPN	S878
HGNC	4662
MGI	1913846
PubMed	9253405
RGD	619746
UniProt	Q92664
Wiki	GTF3A

General Transcription Factor IIIA is a zinc finger protein with nine Cis-His zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes.

The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex.The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.

Reference

"Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA."
Cytogenet. Cell Genet. 70:235-238(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA."
Gene 159:215-218(1995) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human transcription factor IIIA."
J. Biol. Chem. 269:20857-20865(1994) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]