Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)

CD358; BM-018; DR6; Death Receptor 6

SPN	S860
HGNC	13469
MGI	2151075
PubMed	21738152
RGD	1307308
UniProt	O75509
Wiki	TNFRSF21

Tumor necrosis factor receptor superfamily, member 21 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T helper cell activation, and may be involved in inflammation and immune regulation.Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Reference

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"Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein."
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Submitted (DEC-2006) to the PDB data bank

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Acta Crystallogr. D 68:521-530(2012) [PubMed] [Europe PMC] [Abstract]