Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25)

TRAMP; TR3; APO-3; DDR3; DR3; LARD; TNFRSF12; WSL-1; WSL-LR; Translocating Chain-Association Membrane Protein; Lymphocyte-associated receptor of death

SPN	S859
HGNC	11910
MGI	1934667
PubMed	22956587
RGD	1598206
UniProt	Q93038
Wiki	TNFRSF25

TNFRSF25has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules.

The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

Reference

"A death-domain-containing receptor that mediates apoptosis."
Nature 384:372-375(1996) [PubMed] [Europe PMC] [Abstract]

"Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95."
Science 274:990-992(1996) [PubMed] [Europe PMC] [Abstract]

"Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa-B."
Curr. Biol. 6:1669-1676(1996) [PubMed] [Europe PMC] [Abstract]

"LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing."
Proc. Natl. Acad. Sci. U.S.A. 94:4615-4619(1997) [PubMed] [Europe PMC] [Abstract]

"A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas."
Biochem. Biophys. Res. Commun. 242:376-379(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)."
Immunity 6:79-88(1997) [PubMed] [Europe PMC] [Abstract]

"Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."
Science 283:543-546(1999) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]