Retinoic Acid Receptor Beta (RARb)

HAP; NR1B2; RRB2; RAR-epsilon; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2

SPN	S838
HGNC	9865
MGI	97857
PubMed	23376149
RGD	3535
UniProt	P10826
Wiki	RARB

Retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.

Reference

"A new retinoic acid receptor identified from a hepatocellular carcinoma."
Nature 333:669-672(1988) [PubMed] [Europe PMC] [Abstract]

"A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma."
Nature 330:667-670(1987) [PubMed] [Europe PMC] [Abstract]

"Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization."
Proc. Natl. Acad. Sci. U.S.A. 96:8651-8656(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness."
DNA Seq. 2:111-119(1991) [PubMed] [Europe PMC] [Abstract]

"Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines."
Cancer Res. 54:365-369(1994) [PubMed] [Europe PMC] [Abstract]

"Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma."
Nature 322:70-72(1986) [PubMed] [Europe PMC] [Abstract]

"Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma."
Mol. Biol. Med. 7:213-222(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of a second human retinoic acid receptor."
Nature 332:850-853(1988) [PubMed] [Europe PMC] [Abstract]

"Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand."
Mol. Endocrinol. 17:373-385(2003) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements."
Biochemistry 31:6474-6480(1992) [PubMed] [Europe PMC] [Abstract]

"The solution structure of the human retinoic acid receptor-beta DNA-binding domain."
J. Biomol. NMR 3:1-17(1993) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Recessive and dominant mutations in retinoic acid receptor beta in cases with microphthalmia and diaphragmatic hernia."
Am. J. Hum. Genet. 93:765-772(2013) [PubMed] [Europe PMC] [Abstract]