Retinoic Acid Receptor Gamma (RARg)

NR1B3; RARC; Nuclear receptor subfamily 1 group B member 3

SPN	S837
HGNC	9866
MGI	97858
PubMed	20935257
UniProt	P13631
Wiki	RARG

Retinoic acid receptors are retinoic acid-inducible enhancer factors belonging to the superfamily of steroid/thyroid nuclear receptors. A third type of receptor, Retinoic Acid Receptor Gamma, was first identified in the mouse where its RNA was detected predominantly in skin, a well-known target for retinoic acid. Krust et al. (1989) used mouse cDNA to clone the human counterpart. Comparisons of the amino acid sequences of all 6 human and mouse RARs indicated that the interspecies conservation of a given member of the RAR subfamily, i.e., alpha, beta, or gamma, is much higher than the conservation of all 3 receptors in a given species. These observations indicate that the 3 forms of retinoic acid receptor may perform specific functions.

Reference

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Proc. Natl. Acad. Sci. U.S.A. 86:5310-5314(1989) [PubMed] [Europe PMC] [Abstract]

"A functional retinoic acid receptor encoded by the gene on human chromosome 12."
Mol. Endocrinol. 4:837-844(1990) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the retinoic acid receptor gamma gene."
Nucleic Acids Res. 19:573-578(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Murine isoforms of retinoic acid receptor gamma with specific patterns of expression."
Proc. Natl. Acad. Sci. U.S.A. 87:2700-2704(1990) [PubMed] [Europe PMC] [Abstract]

"RAR-gamma-2 expression is regulated through a retinoic acid response element embedded in Sp1 sites."
Mol. Cell. Biol. 12:2976-2985(1992) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid."
Nature 378:681-689(1995) [PubMed] [Europe PMC] [Abstract]

"Conformational adaptation of agonists to the human nuclear receptor RAR gamma."
Nat. Struct. Biol. 5:199-202(1998) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]