Testicular Receptor 4 (TR4)
NR2C2; TAK1; TR2R1; hTAK1; Nuclear Receptor Subfamily 2,Group C,Member 2; Orphan nuclear receptor TAK1
- NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes.
- The cDNAs encode a predicted 615-amino acid human protein and a 596-amino acid rat protein that are 98% identical. The TR4 sequence is similar to that of the TR2 orphan . Together they appear to form a distinct subfamily. The 2 transcripts appeared to differ in the length of the 3-prime untranslated region. In mouse and rat testis, TR4 was expressed most abundantly in spermatocytes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Hu01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Hu01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Hu01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Hu01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Hu01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Mu01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Mu01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Mu01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Mu01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Mu01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Ra01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Ra01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Ra01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Ra01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Ra01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Ca01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Ca01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Ca01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Ca01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Ca01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Po01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Po01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Po01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Po01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Po01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Bo01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Bo01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Bo01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Bo01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Bo01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Rb01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Rb01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Rb01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Rb01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Rb01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS835Mo01 | Recombinant Testicular Receptor 4 (TR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS835Mo01 | Monoclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IP. |
| PAS835Mo01 | Polyclonal Antibody to Testicular Receptor 4 (TR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS835Mo01 | CLIA Kit for Testicular Receptor 4 (TR4) | CLIA assay for Antigen Detection |
| ELS835Mo01 | ELISA Kit for Testicular Receptor 4 (TR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Mol. Endocrinol. 8:1667-1680(1994) [PubMed] [Europe PMC] [Abstract]
"Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily."
Proc. Natl. Acad. Sci. U.S.A. 91:6040-6044(1994) [PubMed] [Europe PMC] [Abstract]
"DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system."
FEBS Lett. 582:2737-2744(2008) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways."
Biochem. Biophys. Res. Commun. 211:83-91(1995) [PubMed] [Europe PMC] [Abstract]
"Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4."
J. Biol. Chem. 273:10948-10957(1998) [PubMed] [Europe PMC] [Abstract]
"Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor."
J. Biol. Chem. 274:16198-16205(1999) [PubMed] [Europe PMC] [Abstract]
"Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation."
J. Biol. Chem. 278:7709-7717(2003) [PubMed] [Europe PMC] [Abstract]
"The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription."
Genes Dev. 21:2832-2844(2007) [PubMed] [Europe PMC] [Abstract]
"Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a."
Endocrinology 149:3490-3499(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"NLRP10 enhances Shigella-induced pro-inflammatory responses."
Cell. Microbiol. 14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]