Nuclear Receptor Related Protein 1 (NURR1)

NR4A2; RNR1; HZF-3; NOT; TINUR; Nuclear Receptor Subfamily 4,Group A,Member 2; Transcriptionally-inducible nuclear receptor; Immediate-early response protein NOT

SPN	S825
HGNC	7981
MGI	1352456
RGD	3202
UniProt	P43354

NURR1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.

A human T-lymphoid cell line, PEER, dies by apoptosis in the presence of phorbol myristate acetate (PMA) and calcium ionophore. The gene encodes a 535-amino acid protein that belongs to the NGFIB/nur77 steroid receptor family.

Reference

"NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
Mol. Endocrinol. 8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs."
Gene 230:233-239(1999) [PubMed] [Europe PMC] [Abstract]

"Organization of the human orphan nuclear receptor Nurr1 gene."
Gene 230:225-232(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line."
J. Immunol. 154:3871-3879(1995) [PubMed] [Europe PMC] [Abstract]

"Induction of tyrosine hydroxylase expression by the transcription factor Pitx3."
Int. J. Dev. Neurosci. 25:29-37(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress."
J. Biol. Chem. 288:5506-5517(2013) [PubMed] [Europe PMC] [Abstract]

"Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors."
Nature 423:555-560(2003) [PubMed] [Europe PMC] [Abstract]