Elongin C (ELOC)

TCEB1; SI; Elo-C; Transcription Elongation Factor B(SIII)Polypeptide 1; Elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C

SPN	S820
HGNC	11617
MGI	1915173
PubMed	12004003
RGD	620658
UniProt	Q15369
Wiki	TCEB1

Transcription elongation factor B polypeptide 1 is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C.

It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3.

Reference

"A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII."
Gene 150:413-414(1994) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity."
Biochem. Biophys. Res. Commun. 276:355-361(2000) [PubMed] [Europe PMC] [Abstract]

"Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays."
Lab. Invest. 82:629-637(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation."
Genes Dev. 18:2861-2866(2004) [PubMed] [Europe PMC] [Abstract]

"TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3."
Oncogene 23:8908-8919(2004) [PubMed] [Europe PMC] [Abstract]

"Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]

"Structural basis for protein recognition by B30.2/SPRY domains."
Mol. Cell 24:967-976(2006) [PubMed] [Europe PMC] [Abstract]

"Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase."
J. Virol. 81:3428-3436(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5."
Mol. Cell 48:692-704(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function."
Science 284:455-461(1999) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL."
Nature 417:975-978(2002) [PubMed] [Europe PMC] [Abstract]

"Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."
Science 296:1886-1889(2002) [PubMed] [Europe PMC] [Abstract]

"Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."
Structure 15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]