Adrenergic Receptor Alpha 2C (ADRa2C)

ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor

SPN	S812
HGNC	283
MGI	87936
PubMed	10334470
RGD	2058
UniProt	P18825
Wiki	ADRA2C

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha_2A and alpha_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha_2C subtype modulated neurotransmission at lower levels of nerve activity.ADRa2C encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

Reference

"Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype."
Proc. Natl. Acad. Sci. U.S.A. 85:6301-6305(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene."
Biochem. J. 328:431-438(1997) [PubMed] [Europe PMC] [Abstract]

"A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors."
J. Biol. Chem. 275:23059-23064(2000) [PubMed] [Europe PMC] [Abstract]

"Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects."
Proc. Natl. Acad. Sci. U.S.A. 101:13020-13025(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR."
FEBS Lett. 280:241-244(1991) [PubMed] [Europe PMC] [Abstract]