Adrenergic Receptor Beta 2 (ADRb2)

B2AR; Beta-2 adrenoreceptor

SPN	S811
HGNC	286
MGI	87938
PubMed	24621682
RGD	2060
UniProt	P07550
Wiki	ADRB2

ADRb2 is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca_V1.2. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

Reference

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