Dimethylarginine Dimethylaminohydrolase 2 (DDAH2)

DDAH; G6A; NG30; N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Dimethylargininase-2; Protein G6a; S-phase protein

SPN	S808
HGNC	2716
MGI	1859016
PubMed	24155659
RGD	1302955
UniProt	O95865

Dimethylarginine dimethylaminohydrolase (DDAH) regulates cellular methylarginine concentrations, which in turn inhibit nitric oxide synthase activity. The DDAHII amino acid sequence shares 98% identity with that of its mouse homolog and 62% identity with the sequence of DDAHI. Northern blot analysis detected a 2.0-kb DDAHII transcript expressed at highest levels in heart, kidney, and placenta.Recombinant DDAHII metabolized ADMA and L-NMMA, but not SDMA or L-arginine, demonstrating that DDAHII is a functional homolog of DDAHI.DDAH2 reduced the secretion of ADMA, increased VEGF mRNA expression, and enhanced tube formation by cells grown in a 3-dimensional medium. A DDAH inhibitor reduced tube formation in human umbilical vein endothelial cells.

Reference

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, Submitted (DEC-2008) to UniProtKB

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