CREB Regulated Transcription Coactivator 1 (CRTC1)

MECT1; TORC1; WAMTP1; Target Of Rapamycin Complex; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1

SPN	S790
HGNC	16062
MGI	2142523
PubMed	20631169
UniProt	Q6UUV9
Wiki	CRTC1

The MECT1 mRNA contains a repetitive element in the 3-prime UTR. Following in vitro translation, the deduced 634-amino acid protein had an apparent molecular mass of 75 kD by SDS-PAGE. expression in brain and kidney, intermediate expression in heart, lung, liver, skeletal muscle, pancreas, testis, and ovary, and little to no expression in spleen. Torc1 was expressed in adult mouse brain and cultured neurons, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways. Nuclear translocation of Torc1 resulted in synergistic activation of Creb-mediated transcription, and Torc1 played a role in activation of brain-derived neurotrophic factor (BDNF) by calcium and cAMP. Torc1 was involved in late-phase long-term potentiation maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.

Reference

"Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]

"t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway."
Nat. Genet. 33:208-213(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 33:408-408(2003)

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract], Colon and Eye.

"Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors."
Exp. Cell Res. 292:21-28(2004) [PubMed] [Europe PMC] [Abstract].

"TORCs: transducers of regulated CREB activity."
Mol. Cell 12:413-423(2003) [PubMed] [Europe PMC] [Abstract]

"Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."
Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]

"Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion."
Genes Chromosomes Cancer 43:202-205(2005) [PubMed] [Europe PMC] [Abstract]

"Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]

"TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."
J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]

"Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."
Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]

"Dephosphorylation of TORC initiates expression of the StAR gene."
Mol. Cell. Endocrinol. 265:196-204(2007) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock."
J. Neurosci. 33:9021-9027(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]