CREB Binding Protein (CREBBP)
CBP; RSTS; RTS; KAT3A; Rubinstein-Taybi Syndrome
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Hu01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Hu01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Hu01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Hu01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Hu01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Mu01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Mu01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Mu01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Mu01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Mu01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Ra01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Ra01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Ra01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Ra01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Ra01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Ca01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Ca01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Ca01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Ca01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Ca01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Po01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Po01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Po01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Po01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Po01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Bo01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Bo01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Bo01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Bo01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Bo01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Rb01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Rb01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Rb01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Rb01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Rb01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS787Mo01 | Recombinant CREB Binding Protein (CREBBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS787Mo01 | Monoclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IP. |
| PAS787Mo01 | Polyclonal Antibody to CREB Binding Protein (CREBBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS787Mo01 | CLIA Kit for CREB Binding Protein (CREBBP) | CLIA assay for Antigen Detection |
| ELS787Mo01 | ELISA Kit for CREB Binding Protein (CREBBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)."
Proc. Natl. Acad. Sci. U.S.A. 94:8732-8737(1997) [PubMed] [Europe PMC] [Abstract]
"Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3."
Genomics 42:96-114(1997) [PubMed] [Europe PMC] [Abstract]
"The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein."
Nat. Genet. 14:33-41(1996) [PubMed] [Europe PMC] [Abstract]
"Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)."
Hum. Mol. Genet. 10:395-404(2001) [PubMed] [Europe PMC] [Abstract]
"A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A."
Nature 382:319-324(1996) [PubMed] [Europe PMC] [Abstract]
"An essential role for p300/CBP in the cellular response to hypoxia."
Proc. Natl. Acad. Sci. U.S.A. 93:12969-12973(1996) [PubMed] [Europe PMC] [Abstract]
"Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300."
Mol. Cell. Biol. 18:2392-2405(1998) [PubMed] [Europe PMC] [Abstract]
"Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases."
Proc. Natl. Acad. Sci. U.S.A. 95:9855-9860(1998) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein."
J. Biol. Chem. 274:16370-16376(1999) [PubMed] [Europe PMC] [Abstract]
"Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling."
Proc. Natl. Acad. Sci. U.S.A. 96:2627-2632(1999) [PubMed] [Europe PMC] [Abstract]
"Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase."
Cell 98:675-686(1999) [PubMed] [Europe PMC] [Abstract]
"The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors."
J. Biol. Chem. 275:8825-8834(2000) [PubMed] [Europe PMC] [Abstract]
"A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
Mol. Cell. Biol. 20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
"Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation."
J. Biol. Chem. 276:10715-10721(2001) [PubMed] [Europe PMC] [Abstract]
"Requirement of two NFATc4 transactivation domains for CBP potentiation."
J. Biol. Chem. 276:39569-39576(2001) [PubMed] [Europe PMC] [Abstract]
"Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."
J. Biol. Chem. 276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]
"The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation."
Mol. Cell. Biol. 21:5520-5530(2001) [PubMed] [Europe PMC] [Abstract]
"Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300."
J. Virol. 75:9885-9895(2001) [PubMed] [Europe PMC] [Abstract]
"A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression."
J. Biol. Chem. 276:33881-33892(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha."
J. Biol. Chem. 276:38272-38279(2001) [PubMed] [Europe PMC] [Abstract]
"HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators."
Oncogene 20:800-811(2001) [PubMed] [Europe PMC] [Abstract]
"Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb."
Cell Growth Differ. 13:69-75(2002) [PubMed] [Europe PMC] [Abstract]
"Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."
J. Biol. Chem. 277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
"Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase."
Mol. Cell. Biol. 22:3549-3561(2002) [PubMed] [Europe PMC] [Abstract]
"Interferon regulatory factor-2 regulates cell growth through its acetylation."
J. Biol. Chem. 278:25401-25407(2003) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination."
J. Biol. Chem. 278:26102-26110(2003) [PubMed] [Europe PMC] [Abstract]
"P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain."
J. Bone Miner. Res. 18:1419-1429(2003) [PubMed] [Europe PMC] [Abstract]
"Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
"Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86."
J. Biol. Chem. 279:25241-25250(2004) [PubMed] [Europe PMC] [Abstract]
"FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)."
J. Biol. Chem. 279:28873-28879(2004) [PubMed] [Europe PMC] [Abstract]
"The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies."
Neurosci. Lett. 370:191-195(2004) [PubMed] [Europe PMC] [Abstract]
"Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity."
Proc. Natl. Acad. Sci. U.S.A. 101:10042-10047(2004) [PubMed] [Europe PMC] [Abstract]
"Dendrite development regulated by CREST, a calcium-regulated transcriptional activator."
Science 303:197-202(2004) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB."
Mol. Cell 26:75-87(2007) [PubMed] [Europe PMC] [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
"Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1."
Cancer Res. 68:1478-1484(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis."
Nucleic Acids Res. 42:8433-8448(2014) [PubMed] [Europe PMC] [Abstract]
"Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response."
Proc. Natl. Acad. Sci. U.S.A. 99:5271-5276(2002) [PubMed] [Europe PMC] [Abstract]
"Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein."
EMBO J. 20:7184-7196(2001) [PubMed] [Europe PMC] [Abstract]
"NMR mapping of the HIV-1 Tat interaction surface of the KIX domain of the human coactivator CBP."
Biochemistry 43:904-908(2004) [PubMed] [Europe PMC] [Abstract]
"Histone recognition and large-scale structural analysis of the human bromodomain family."
Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]
"Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation."
Proc. Natl. Acad. Sci. U.S.A. 111:E1072-E1081(2014) [PubMed] [Europe PMC] [Abstract]
"Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP."
Structure 22:353-360(2014) [PubMed] [Europe PMC] [Abstract]
"Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome."
Hum. Mol. Genet. 10:1071-1076(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular studies in 10 cases of Rubinstein-Taybi syndrome, including a mild variant showing a missense mutation in codon 1175 of CREBBP."
J. Med. Genet. 39:496-501(2002) [PubMed] [Europe PMC] [Abstract]
"Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome."
Hum. Mol. Genet. 12:441-450(2003) [PubMed] [Europe PMC] [Abstract]
"Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease."
Am. J. Hum. Genet. 76:572-580(2005) [PubMed] [Europe PMC] [Abstract]
"Inheritance and variable expression in Rubinstein-Taybi syndrome."
Am. J. Med. Genet. A 152A:2254-2261(2010) [PubMed] [Europe PMC] [Abstract]
"Insights into genotype-phenotype correlations from CREBBP point mutation screening in a cohort of 46 Rubinstein-Taybi syndrome patients."
Clin. Genet. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]