Defensin Alpha 3, Neutrophil Specific (DEFa3)

HNP3; DEF3; HNP-2; Neutrophil defensin 2

SPN	S648
HGNC	2762
PubMed	20502117
UniProt	P59666
Wiki	DEFA3

DEFA1 and DEFA3 differ from each other only by their N-terminal amino acids (ala and asp, respectively). DEFA2 is identical to both except that it lacks this N-terminal amino acid.DEFA1-, DEFA2-, and DEFA3-specific antibodies depleted antiviral activity in a dose-dependent manner, particularly against viruses using CXCR4 rather than CCR5 as a coreceptor. Addition of synthetic or purified natural defensins inhibited HIV-1 replication in vitro.

Flow cytometric analysis determined that in addition to neutrophils, a small population of CD8-positive T lymphocytes harbor and secrete DEFA1, DEFA2, and DEFA3. Zhang et al. (2002) proposed that these defensins account for much of the anti-HIV-1 activity of CAF that is not attributable to beta chemokines.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Hu01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Hu01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Hu01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Hu01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Hu01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Mu01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Mu01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Mu01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Mu01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Mu01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Ra01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Ra01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Ra01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Ra01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Ra01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Ca01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Ca01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Ca01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Ca01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Ca01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Po01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Po01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Po01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Po01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Po01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Bo01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Bo01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Bo01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Bo01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Bo01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Rb01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Rb01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Rb01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Rb01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Rb01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS648Mo01	Recombinant Defensin Alpha 3, Neutrophil Specific (DEFa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS648Mo01	Monoclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IP.
Antibodies	PAS648Mo01	Polyclonal Antibody to Defensin Alpha 3, Neutrophil Specific (DEFa3)	WB; IHC; ICC; IF.
Assay Kits	CLS648Mo01	CLIA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	CLIA assay for Antigen Detection
Assay Kits	ELS648Mo01	ELISA Kit for Defensin Alpha 3, Neutrophil Specific (DEFa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation and characterization of human defensin cDNA clones."
Proc. Natl. Acad. Sci. U.S.A. 85:7327-7331(1988) [PubMed] [Europe PMC] [Abstract]

"Differentiation stage-specific expression of a gene during granulopoiesis."
Leukemia 3:227-234(1989) [PubMed] [Europe PMC] [Abstract]

"The structure of neutrophil defensin genes."
FEBS Lett. 321:267-273(1993) [PubMed] [Europe PMC] [Abstract]

Erratum
FEBS Lett. 326:299-300(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Primary structures of three human neutrophil defensins."
J. Clin. Invest. 76:1436-1439(1985) [PubMed] [Europe PMC] [Abstract]

"Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide."
J. Biol. Chem. 264:4003-4007(1989) [PubMed] [Europe PMC] [Abstract]

"Posttranslational processing of defensins in immature human myeloid cells."
Blood 79:1538-1544(1992) [PubMed] [Europe PMC] [Abstract]

"Antibacterial activity and specificity of the six human alpha-defensins."
Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization."
Science 251:1481-1485(1991) [PubMed] [Europe PMC] [Abstract]

"Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids."
J. Biol. Chem. 280:32921-32929(2005) [PubMed] [Europe PMC] [Abstract]

"Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs."
J. Biol. Chem. 282:19653-19665(2007) [PubMed] [Europe PMC] [Abstract]