Defensin Alpha 1B (DEFa1B)
HNP-1; DEFA2; MRS; Neutrophil defensin 1
- Defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates. They have also been reported in plants. They are active against bacteria, fungi and many enveloped and nonenveloped viruses. They consist of 18-45 amino acids including six (in vertebrates) to 8 conserved cysteine residues. Cells of the immune system contain these peptides to assist in killing phagocytized bacteria, for example in neutrophil granulocytes and almost all epithelial cells. Most defensins function by binding to microbial cell membrane, and once embedded, forming pore-like membrane defects that allow efflux of essential ions and nutrients. α-defensins expressed primarily in neutrophils as well as in NK cells and certain T-lymphocyte subsets. DEFA5 and DEFA6 are expressed in Paneth cells of the small intestine, where they may regulate and maintain microbial balance in the intestinal lumen.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Hu01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Hu01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Hu01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Hu01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Hu01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Mu01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Mu01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Mu01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Mu01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Mu01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Ra01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Ra01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Ra01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Ra01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Ra01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Ca01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Ca01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Ca01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Ca01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Ca01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Po01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Po01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Po01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Po01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Po01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Bo01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Bo01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Bo01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Bo01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Bo01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Rb01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Rb01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Rb01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Rb01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Rb01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS647Mo01 | Recombinant Defensin Alpha 1B (DEFa1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS647Mo01 | Monoclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IP. |
| PAS647Mo01 | Polyclonal Antibody to Defensin Alpha 1B (DEFa1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS647Mo01 | CLIA Kit for Defensin Alpha 1B (DEFa1B) | CLIA assay for Antigen Detection |
| ELS647Mo01 | ELISA Kit for Defensin Alpha 1B (DEFa1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and characterization of human defensin cDNA clones."
Proc. Natl. Acad. Sci. U.S.A. 85:7327-7331(1988) [PubMed] [Europe PMC] [Abstract]
"A myeloid-related sequence that localizes to human chromosome 8q21.1-22."
Blood 71:1713-1719(1988) [PubMed] [Europe PMC] [Abstract]
"Differentiation stage-specific expression of a gene during granulopoiesis."
Leukemia 3:227-234(1989) [PubMed] [Europe PMC] [Abstract]
"Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3."
J. Biol. Chem. 270:30371-30376(1995) [PubMed] [Europe PMC] [Abstract]
"The structure of neutrophil defensin genes."
FEBS Lett. 321:267-273(1993) [PubMed] [Europe PMC] [Abstract]
Erratum
FEBS Lett. 326:299-300(1993) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Primary structures of three human neutrophil defensins."
J. Clin. Invest. 76:1436-1439(1985) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide."
J. Biol. Chem. 264:4003-4007(1989) [PubMed] [Europe PMC] [Abstract]
"The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells."
J. Biol. Chem. 266:7524-7530(1991) [PubMed] [Europe PMC] [Abstract]
"Posttranslational processing of defensins in immature human myeloid cells."
Blood 79:1538-1544(1992) [PubMed] [Europe PMC] [Abstract]
"Antibacterial activity and specificity of the six human alpha-defensins."
Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]
"Structural and functional consequences induced by post-translational modifications in alpha-Defensins."
Int. J. Pept. 2011:594723-594723(2011) [PubMed] [Europe PMC] [Abstract]
"NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1."
Biochemistry 31:11348-11356(1992) [PubMed] [Europe PMC] [Abstract]
"NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1."
Biochemistry 31:11357-11364(1992) [PubMed] [Europe PMC] [Abstract]
"Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs."
J. Biol. Chem. 282:19653-19665(2007) [PubMed] [Europe PMC] [Abstract]