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Defensin Alpha 4, Corticostatin (DEFa4)

DEF4; HP-4; HNP-4; Neutrophil defensin 4

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region.DEFa4 is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.The nucleotide sequence shares about 72% identity with the cDNA encoding defensin HP-1 , but differed from it and from other genes of this family by an extra 83-base segment. This extra segment was not adjacent to an intron and was apparently the result of a recent duplication within the coding region corresponding to most of the mature HP-4 peptide.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Hu01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Hu01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Hu01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Hu01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Hu01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Mu01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Mu01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Mu01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Mu01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Mu01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Ra01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Ra01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Ra01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Ra01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Ra01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Ca01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Ca01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Ca01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Ca01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Ca01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Po01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Po01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Po01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Po01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Po01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Bo01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Bo01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Bo01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Bo01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Bo01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Rb01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Rb01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Rb01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Rb01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Rb01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS646Mo01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS646Mo01 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAS646Mo01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IF.
Assay Kits CLS646Mo01 CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA assay for Antigen Detection
ELS646Mo01 ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8."
Mol. Endocrinol. 7:199-205(1993) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of a novel human granulocyte peptide with anti-ACTH activity."
Biochem. Biophys. Res. Commun. 155:524-529(1988) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family."
J. Biol. Chem. 264:11200-11203(1989) [PubMed] [Europe PMC] [Abstract]

"Antibiotic proteins of human polymorphonuclear leukocytes."
Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]

"Antibacterial activity and specificity of the six human alpha-defensins."
Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]

"Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro."
FEBS Lett. 579:162-166(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of human alpha-defensins HNP4, HD5, and HD6."
Protein Sci. 15:2749-2760(2006) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]