Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2)
PC2; NEC2; SPC2; Prohormone Convertase 2; Neuroendocrine Convertase 2; KEX2-Like Endoprotease 2; Proprotein convertase 2
Proprotein convertase 2 is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1. PC2 binds to the neuroendocrine protein named 7B2, and if this protein is not present, proPC2 cannot become enzymatically active.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Hu01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Hu01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Hu01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Hu01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Hu01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Mu01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Mu01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Mu01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Mu01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Mu01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Ra01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Ra01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Ra01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Ra01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Ra01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Ca01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Ca01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Ca01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Ca01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Ca01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Po01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Po01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Po01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Po01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Po01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Bo01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Bo01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Bo01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Bo01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Bo01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Rb01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Rb01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Rb01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Rb01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Rb01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS603Mo01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS603Mo01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IP. |
| PAS603Mo01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS603Mo01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | CLIA assay for Antigen Detection |
| ELS603Mo01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2."
J. Biol. Chem. 265:2997-3000(1990) [PubMed] [Europe PMC] [Abstract]
"Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues."
Proc. Natl. Acad. Sci. U.S.A. 89:4977-4981(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the gene encoding human PC2, a prohormone processing enzyme."
Nippon Rinsho 52:2544-2549(1994) [PubMed] [Europe PMC] [Abstract]
"Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon."
FEBS Lett. 413:119-123(1997) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]