Call Now

Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2)

PC2; NEC2; SPC2; Prohormone Convertase 2; Neuroendocrine Convertase 2; KEX2-Like Endoprotease 2; Proprotein convertase 2

Proprotein convertase 2 is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1. PC2 binds to the neuroendocrine protein named 7B2, and if this protein is not present, proPC2 cannot become enzymatically active.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Hu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Hu01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Hu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Hu01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Hu01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Mu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Mu01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Mu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Mu01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Mu01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Ra01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Ra01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Ra01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Ra01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Ra01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Ca01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Ca01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Ca01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Ca01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Ca01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Po01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Po01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Po01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Po01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Po01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Bo01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Bo01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Bo01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Bo01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Bo01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Rb01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Rb01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Rb01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Rb01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Rb01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS603Mo01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS603Mo01 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IP.
PAS603Mo01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) WB; IHC; ICC; IF.
Assay Kits CLS603Mo01 CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) CLIA assay for Antigen Detection
ELS603Mo01 ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2."
J. Biol. Chem. 265:2997-3000(1990) [PubMed] [Europe PMC] [Abstract]

"Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues."
Proc. Natl. Acad. Sci. U.S.A. 89:4977-4981(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the gene encoding human PC2, a prohormone processing enzyme."
Nippon Rinsho 52:2544-2549(1994) [PubMed] [Europe PMC] [Abstract]

"Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon."
FEBS Lett. 413:119-123(1997) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]