Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6)
PACE4; SPC4; Paired Basic Amino Acid Cleaving System 4; Subtilisin-Like Proprotein Convertase 4; Subtilisin/Kexin-Like Protease PACE4
Proprotein convertase subtilisin/kexin type 6 is an enzyme that belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Each PACE4 isoform exhibits a unique restricted distribution. PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. PACE4A-II is at least expressed in placenta. PACE4B was only found in the embryonic kidney cell line from which it was isolated. PACE4C and PACE4D are expressed in placenta.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Hu01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Hu01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Hu01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Hu01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Hu01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Mu01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Mu01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Mu01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Mu01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Mu01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Ra01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Ra01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Ra01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Ra01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Ra01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Ca01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Ca01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Ca01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Ca01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Ca01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Po01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Po01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Po01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Po01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Po01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Bo01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Bo01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Bo01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Bo01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Bo01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Rb01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Rb01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Rb01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Rb01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Rb01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS599Mo01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS599Mo01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IP. |
| PAS599Mo01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS599Mo01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | CLIA assay for Antigen Detection |
| ELS599Mo01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15."
DNA Cell Biol. 10:757-769(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms."
Biochem. Biophys. Res. Commun. 200:943-950(1994) [PubMed] [Europe PMC] [Abstract]
Erratum
Biochem. Biophys. Res. Commun. 204:1381-1382(1994) [PubMed] [Europe PMC] [Abstract]
"A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus."
J. Biochem. 121:941-948(1997) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease."
J. Biochem. 122:438-452(1997) [PubMed] [Europe PMC] [Abstract]
"Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform."
FEBS Lett. 396:31-36(1996) [PubMed] [Europe PMC] [Abstract]
"Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain."
Biochem. J. 339:639-647(1999) [PubMed] [Europe PMC] [Abstract]
"Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)."
FEBS Lett. 434:155-159(1998) [PubMed] [Europe PMC] [Abstract]