Elastase 2A (ELA2A)
ELA1; PE-1; CELA2A; Chymotrypsin-Like Elastase Family Member 2A
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.
The deduced 269-amino acid protein shares 55 to 84% identity with other mammalian elastases and 39% identity with bovine chymotrypsin A. Most homology resides in the N-terminal sequence and in the C-terminal half of the protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Hu01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Hu01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Hu01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Hu01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Hu01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Mu01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Mu01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Mu01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Mu01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Mu01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Ra01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Ra01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Ra01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Ra01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Ra01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Ca01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Ca01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Ca01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Ca01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Ca01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Po01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Po01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Po01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Po01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Po01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Bo01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Bo01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Bo01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Bo01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Bo01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Rb01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Rb01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Rb01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Rb01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Rb01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS576Mo01 | Recombinant Elastase 2A (ELA2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS576Mo01 | Monoclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IP. |
| PAS576Mo01 | Polyclonal Antibody to Elastase 2A (ELA2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS576Mo01 | CLIA Kit for Elastase 2A (ELA2A) | CLIA assay for Antigen Detection |
| ELS576Mo01 | ELISA Kit for Elastase 2A (ELA2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA."
Biochemistry 26:7256-7261(1987) [PubMed] [Europe PMC] [Abstract]
"Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas."
DNA 6:163-172(1987) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2."
J. Biochem. 102:1555-1563(1987) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Further studies on the human pancreatic binary complexes involving procarboxypeptidase A."
FEBS Lett. 261:179-183(1990) [PubMed] [Europe PMC] [Abstract]
"Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism."
J. Invest. Dermatol. 114:165-170(2000) [PubMed] [Europe PMC] [Abstract]