Apoptosis Inhibitor 5 (API5)

MIG8; FIF; AAC11; API5L1; XAGL; Cell migration-inducing gene 8; Antiapoptosis clone 11; Fibroblast Growth Factor 2-Interacting Factor 2; Migration-Inducing Protein MIG8

SPN	S551
HGNC	594
MGI	1888993
PubMed	23940755
RGD	1309772
UniProt	Q9BZZ5
Wiki	API5

AAC11 was cloned by database analysis and screening gingiva and leukemia cDNA libraries. The deduced 504-amino acid human protein shares a high degree of identity with the long mouse protein. AAC11 contains several protein phosphorylation sites, 2 N-glycosylation sites, and a leucine-rich sequence with weak similarity to a leucine zipper motif. Northern blot analysis detected a major Aac11 transcript in all adult and embryonic mouse tissues examined and several other transcripts expressed in a tissue-specific manner. AAC11 expression was also detected in several human tumor cell lines. Western blot analysis of mouse fibroblasts detected a major 55-kD protein and a minor 25-kD protein, corresponding to the long and short Aac11 isoforms, respectively.

Reference

"AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal."
Cancer Res. 57:4063-4069(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene."
Cytogenet. Cell Genet. 84:164-166(1999) [PubMed] [Europe PMC] [Abstract]

"FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2."
Mol. Endocrinol. 14:1709-1724(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]