Beta-Carotene-15,15'-Monooxygenase 1 (bCMO1)

BCO1; BCDO; BCDO1; BCMO; Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1; Beta,beta-carotene 15,15'-monooxygenase

SPN	S539
HGNC	13815
MGI	1926923
PubMed	21673813
RGD	70981
UniProt	Q9HAY6

Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. Beta-carotene 15,15-prime-monooxygenase (EC 1.13.11.21) is a key enzyme in beta-carotene metabolism to vitamin A.

Beta Carotene 15,15-Monooxygenase 1 a protein that shares 36.7% sequence identity with the bovine retinal pigment epithelium-specific gene Rpe65. They found that recombinant Drosophila Bcdo catalyzes centric cleavage of beta-carotene, resulting in the formation of 2 molecules of retinal. RT-PCR detected Bcdo expression exclusively in Drosophila head. Bcmo1 as critical molecular player for the regulation of PPARγ activity in adipocytes.

Reference

"Cloning and characterization of a human beta,beta-carotene-15,15-prime dioxygenase that is highly expressed in the retinal pigment epithelium."
Genomics 72:193-202(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Loss-of-function mutation in carotenoid 15,15'-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A."
J. Nutr. 137:2346-2350(2007) [PubMed] [Europe PMC] [Abstract]