B-Lymphoid Tyrosine Kinase (BLK)

Tyrosine-protein kinase BLK; p55-Blk

SPN	S516
HGNC	1057
MGI	88169
PubMed	24023612
RGD	1308859
UniProt	P51451
Wiki	BLK

The BLK gene is a nonreceptor protein tyrosine kinase with a calculated molecular mass of about 58 kD. It has an overall amino acid identity of approximately 87% to the mouse Blk; however, in the unique domain of Src family members there is only 58% homology and an insertion of 6 amino acids in the N-terminal region. The nature of this insertion suggested a functional role in membrane attachment. Mutation screening of each exon by direct sequencing of genomic DNA from KWE patients did not reveal any pathogenic mutation. Because BLK is a member of the SRC family, which is thought to play an important role in the signaling pathways controlling cell proliferation and differentiation, the authors considered the gene to be a good positional candidate for the cancers mapping to this region.

Reference

"Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk."
J. Immunol. 154:1265-1272(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)."
Oncogene 10:477-486(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor."
J. Biol. Chem. 269:22921-22924(1994) [PubMed] [Europe PMC] [Abstract]

"In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]

"Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development."
J. Immunol. 163:5453-5461(1999) [PubMed] [Europe PMC] [Abstract]

"IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts."
Biochem. J. 364:517-525(2002) [PubMed] [Europe PMC] [Abstract]

"Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction."
Proc. Natl. Acad. Sci. U.S.A. 106:14460-14465(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]